Search results for " ligand-binding assays"
Article
Ligand-Binding Assays and the Determination of Biosimilarity
Consequently, functional assays, such as ligand-binding assays (LBAs) and mechanism of action (MOA) cell-based assays (CBAs), must be developed to effectively assess biosimilars. In many cases, LBAs a…
Article
Applications of Surface Plasmon Resonance for Detection of Bispecific Antibody Activity
SPR and ELISA are extensively used in ligand-binding assays. SPR analysis has been used for antibody characterization for more than 20 years. The sample readout from an SPR system such as Biacore (Cyt…
Article
An Analytical Approach to Biosimilar Drug Development
Automation has been key in allowing ligand-binding assays to meet the intense throughput and turnaround requirements of biosimilar studies.
References
1. J. Yuan, W.W. Xu, and H.F. P…
Article
Sensitive and Reproducible SPR-Based Concentration and Ligand-Binding Analyses
Surface plasmon resonance (SPR) assays are used across the life cycle of a biopharmaceutical, from target identification, through CQA determination, development, and on-going quality control. This art…
Article
Sensitive and Reproducible SPR-Based Concentration and Ligand-Binding Analyses
Surface plasmon resonance (SPR) assays are used across the life cycle of a biopharmaceutical, from target identification, through CQA determination, development, and on-going quality control. This art…
Article
Biacore Concentration and Ligand-Binding Analyses
Biotherapeutic drugs including antibodies, cytokines, and hormones are used for treatment of a variety of diseases including arthritis, cancer, and diabetes. Compared to traditional small-molecule dru…